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The complexity and specificity of cellular processes require spatial micro-compartmentation and dynamic modulation of the underlying biochemical activities, such as dynamic phosphorylation and dephosphorylation catalyzed by specific protein kinases and phosphatases, respectively. We hypothesize that cellular biochemical activities are spatially organized into an “activity architecture�� and reorganization and restructuring of this activity architecture lead to disease. In this talk, I will introduce a series of genetically encoded or chemigenetic fluorescent biosensors that we have developed to monitor biochemical events in living cells, and then present a couple of studies where we combine quantitative fluorescence imaging with targeted perturbations as well as biochemical and functional assays to probe the spatiotemporal regulation of cell signaling.

Speaker

• Prof. Jin Zhang, Professor, University of California San Diego, Dr. Jin Zhang received her Bachelor’s degree from Tsinghua University and her PhD in Chemistry from University of Chicago in 2000. AŌer compleƟng her postdoctoral work in the laboratory of the late Roger Tsien at UC San Diego, she joined the faculty of Johns Hopkins University School of Medicine in 2003. She was promoted to Professor of Pharmacology in 2013. In 2015 she moved back to UC San Diego and is currently Professor and vice Chair in the Department of Pharmacology.
• Research in her lab focuses on developing enabling technologies to probe the active molecules in their native environment and characterizing how these active molecules change in diseases including cancer. Dr Zhang is a recipient of the Biophysical �й�365bet���Ĺ��� Margaret Oakley Dayhoff Award (2009), NIH Director’s Pioneer Award (2009), John J. Abel Award in Pharmacology (2012), Pfizer Award in Enzyme Chemistry (2012), NCI Outstanding Investigator Award (2015 and 2022), Robert R. Ruffolo Career Achievement Award in Pharmacology (2022), Protein �й�365bet���Ĺ��� Christian B. Anfinsen Award (2022) and Biophysical �й�365bet���Ĺ��� Carolyn Cohen Innovation Award from (2023).