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Azadirachtin is an impressive molecule. It contains eight rings (five of which incorporate oxygen atoms), 16 chiral centers, and three quaternary carbon atoms. Its functionalities include a hydroxyl group, an enol ether, an acetal, two hemiacetals, an epoxide, and four carboxylic acid esters.

Synthetic organic chemists had a tough time synthesizing azadirachtin, but it came naturally to the neem tree (Azadirachta indica), a member of the mahogany family that grows in India, Iran, and parts of Africa. Azadirachtin, along with many related compounds, is found in neem seeds, leaves, and bark. Its biosynthetic pathway has not been completely elucidated.

For centuries, the seeds and leaves of A. indica have been known to . In the 1960s, chemists began to study neem seed extracts to determine the active ingredients. J. H. Butterworth and E. D. Morgan at the University of Keele (UK) as the key molecule in 1968. Stephen V. Ley and four co-workers at the University of Cambridge (UK) completed its in 2007.

Azadirachtin is a white microcrystalline solid with a strong garlicky or sulfurous odor, which is a bit strange because it contains no sulfur. Perhaps the odor is what repels insects. In any case, neem oil (extracted from the seeds) is used in many commercial pesticides and growth regulators. Although azadirachtin has some toxic properties (see hazard information table), it is harmless to mammals in the amounts normally used. As the table also shows, however, it brings some environmental concerns.

Azadirachtin has another, perhaps unexpected, use. Much of the Indian population chews neem twigs or uses them as brushes to clean their teeth. Taking things further, neem bark, leaves, and oil are used in many 鈥渘atural鈥� toothpastes. You can purchase all of these products in health food stores or online.