What molecule am I?
Beclomethasone dipropionate (aka beclometasone) is a venerable steroidal drug with a variety of uses. It was first described in a 1964 Belgian patent to the Glaxo Group (Greenford, UK; now part of GSK) titled 鈥淭opically active anti-inflammatory 17-mono- and 17,21-diesters of betamethasone1 and its 9-chloro-analogs, compositions and use thereof鈥�. Three years later, an equivalent patent was issued as US 3,312,590.
Beclomethasone dipropionate was first approved by the US Food and Drug Administration in 1976 as a nasal spray for treating asthma. Since then, FDA approved it in inhalers for treatment (2000) and as a nasal spray for (2012).
Versatile beclomethasone dipropionate is used in creams such as psoriasis, eczema, dermatitis, and allergies. It is also available in topical and tablet forms for .
1. CAS Reg. No. 378-44-9.
Beclomethasone dipropionate hazard information*
| Hazard class** | GHS code and hazard statement | |
|---|---|---|
| Skin sensitization, category 1 | H317鈥擬ay cause an allergic skin reaction |  |
| Reproductive toxicity, category 1B | H360鈥擬ay damage fertility or the unborn child |  |
| Specific target organ toxicity, repeated exposure (adrenal gland, immune system, bone), category 2 | H373鈥擬ay cause damage to organs through prolonged or repeated exposure | |
| Long-term (chronic) aquatic hazard, category 4 | H413鈥擬ay cause long-lasting harmful effects to aquatic life | |
*Compilation of multiple safety data sheets. The greatest reported hazard is shown for each hazard class.
**Globally Harmonized System (GHS) of Classification and Labeling of Chemicals.听.
Molecules from the Journals
Cannabichromene1 (CBC) is one of hundreds of cannabinoids found in plants of the Cannabis genus. In 1966, U. Claussen, F. von Spulak, and F. Korte* at the University of Bonn (Germany) reported its isolation and identification as the .
As a nonpsychoactive cannabinoid, CBC is well known as an analgesic component of Cannabis; but not until last month was its human metabolism understood. David Sarlah, Aditi Das, and collaborators at the University of Illinois at Urbana鈥揅hampaign, Georgia Tech (Atlanta), and the University of California, San Francisco, elucidated the mechanism by which to produce two major metabolites, 8鈥�-hydroxy-CBC and 6鈥�,7鈥�-epoxy-CBC. The authors also identified the specific P450 that most efficiently produces these metabolites.
See also the 2023 Molecules from the Journals entry for CBC.
Ferberite2 is a mineral that was discovered in Spain in 1963 and named after German mineralogist Moritz Rudolph Ferber. It is composed of iron(II) tungstate3 (FeWO4).
In March, Sinhu茅 L贸pez-Moreno, Daniel Errandonea, and colleagues at the San Luis Potos铆 Institute of Scientific Research and Technology (Mexico), the University of Valencia (Spain), and other Spanish institutions reported the at pressures as high as 20 GPa. Among their findings: The wolframite structure of FeWO4 did not change over the pressure range studied; this result is typical of wolframite compounds of the form MWO4, in which M is a metal. The authors also found that their Raman spectra of FeWO4 in ferberite agreed with previous measurements of synthetic FeWO4 and were similar to the spectra of the wolframite MgWO44.
1. CAS Reg. No. 20675-51-8.
2. CAS Reg. No. 13871-23-3.
3. CAS Reg. No. 13870-24-1.
4. CAS Reg. No. 13573-11-0.
Molecules from the Journals
MOTW briefly describes noteworthy molecules that appeared in recent ACS journal articles. See this week's edition.
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Beclomethasone dipropionate听
fast facts
| CAS Reg. No. | 5534-09-8 |
| SciFindern name | Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11尾,16尾)- |
| Empirical formula | C28H37ClO7 |
| Molar mass | 521.04 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting point | 117鈥�120 掳C |
| Water solubility | 0.16 mg/L |
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