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N-(n-Butyl)thiophosphoric triamide (NBPT) is a specialty fertilizer additive. It was first reported in 1956 by Margot Goehring*1 and Kurt Niedenzu at the University of Heidelberg (West Germany). The authors described processes for making phosphoramide2 [PO(NH2)3], as well as , including NBPT.
NBPT inhibits the enzyme urease, a widespread component of soil microorganisms. Urease converts urea, a commonly used nitrogen fertilizer, to ammonia, which can volatilize before it is absorbed by crops. NBPT is called an enhanced efficiency nitrogen fertilizer (EENF) because it fosters improved intake of nitrogen, potentially allowing the grower to decrease the amount of urea applied to a crop.
NBPT has been used successfully in agriculture for more than 20 years. A 2018 review by Heitor Cantarella and coauthors at the Agronomic Institute of Campinas and other Brazilian institutions described the compound鈥檚 effectiveness but to lengthen the period of urease inhibition and to increase shelf life.
In 2019, as if on cue from Cantarella et al., Ahmed A. Lasisi, Olalekan O. Akinremi*, and Darshani Kumaragamage at the University of Manitoba (Winnipeg, Canada) and the University of Winnipeg reported an NBPT formulation that lowered the required concentration of the EENF in urea and urea鈥揳mmonium nitrate fertilizers without decreasing urease-inhibition performance. The formulation included a new polymer that and extends the usability of the product at low temperatures.
1. Goehring was the first female rector at a West German university.
2. CAS Reg. No. 13597-72-3.
N-(n-Butyl)thiophosphoric triamide听hazard information*
| Hazard class** | GHS code and hazard statement | |
|---|---|---|
| Acute toxicity, oral, category 4 | H302鈥擧armful is swallowed |  |
| Skin corrosion/irritation, category 2 | H315鈥擟auses skin irritation | |
| Serious eye damage/eye irritation, category 1 | H318鈥擟auses serious eye damage |  |
| Specific target organ toxicity, single exposure, respiratory tract irritation, category 3 | H335鈥擬ay cause respiratory irritation | |
| Specific target organ toxicity, single exposure, narcotic effects, category 3 | H336鈥擬ay cause drowsiness or dizziness | |
| Reproductive toxicity, category 2 | H361鈥擲uspected of damaging fertility or the unborn child |  |
*Compilation of multiple safety data sheets; in each class, the most hazardous category is shown.
**Globally Harmonized System (GHS) of Classification and Labeling of Chemicals.听.
Molecules from the journals
Gallium phosphide1 (GaP) is an inorganic compound that is a useful semiconductor in optical systems and light-emitting diodes. It is an orange solid with a melting point of 1457 掳C.
GaP was first described in 1952 by Heinrich Welker at Siemens-Schuckert (Erlangen, West Germany); he compared the semiconductor properties of binary compounds of group 13 and group 15 elements with those made solely from group 14 elements.2 Two years later, O. G. Folberth und F. Oswald, also at Siemens-Schuckert, elaborated on the semiconductor properties of GaP.
More recently, GaP has shown value as a photocatalyst. Earlier this month, Frank E. Osterloh and co-workers at the University of California, Davis, reported that GaP particles, together with a nickel phosphide3 cocatalyst, promoted the evolution of hydrogen from water under 525-nm irradiation with a .
(+)-Archangiumide4 is a macrocyclic natural product that contains an allene (C=C=C) moiety in its ring, only the second such compound to be discovered. This finding was reported in 2021 by Yue-Zhong Li, Changsheng Wu, and colleagues at Shandong University (Qingdao, China), who described the from the myxobacterium Archangium violaceum.
This past January, Jack L. Sutro and Alois F眉rstner* at the Max Planck Institute for Coal Research (M眉lheim an der Ruhr, Germany) reported the . The allenic group was formed in the last step of the 13-step synthetic sequence.听
1. CAS Reg. No. 12063-98-8.
2. At the time, the groups were known as 3 through 5.
3. CAS Reg. No. 12035-64-2.
4. As of this writing, a CAS Reg. No. has not been assigned to this molecule.
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N-(n-Butyl)thiophosphoric triamide听fast facts
| CAS Reg. No. | 94317-64-3 |
| CA Index Name | Phosphorothioic triamide, N-butyl- |
| Empirical formula | C4H14N3PS |
| Molar mass | 167.21 g/mol |
| Appearance | White powder |
| Melting point | 56鈥�58 掳C |
| Water solubility | 4.3 g/L (25 掳C) |
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