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November is flavor and aroma month!

Cuminaldehyde, an aromatic aldehyde, gets its name from one of its main natural sources: the cumin plant (Cuminum cyminum) that grows in countries from Turkey across to India. In addition to cumin, cuminaldehyde is found in the essential oils of eucalyptus, myrrh, and cassia.

In small amounts, cuminaldehyde has a pleasant, herbal aroma; however, it also has an acrid, burning taste. As the hazard information table shows, direct exposure can have some unpleasant consequences.

Cumin has been used as a flavoring agent for centuries; cuminaldehyde has been in the chemical literature since at least the 1880s. In volume 2 (1880) of the Journal of the American Chemical Öйú365betÖÐÎĹÙÍø (then called the American Chemical Journal), an abstract of an article about derivatives of stilbene (1,2-diphenylethylene) describes a reaction acid to form isopropylstilbene.

Almost 70 years later, Nathan N. Crounse at the Hilton-Davis Chemical Co. (Cincinnati) reported a that uses the high-pressure Gattermann–Koch reaction to formylate cumene (isopropylbenzene) with carbon monoxide. The aldehyde can also be prepared by the reduction of p-isopropylbenzoyl chloride.

Today, most commercial cuminaldehyde is synthetic. It is sold as an ingredient for flavoring agents, perfumes, and other aroma-containing products. It also has several purported medicinal uses (e.g., against pain, inflammation, nausea, and skin conditions), but the effects are largely anecdotal. A derivative, cuminaldehyde thiosemicarbazone¹, has been studied for activity against the and .

A final note: Cumin is the main flavor ingredient in taco sauce. The next time you go out for Taco Tuesday, you have cuminaldehyde to thank.

1. CAS Reg. No. 3811-20-9.