Guaiacol, or聽o-methoxyphenol, was first isolated from the tree resin guaiac by A. Sobrero in 1843. Today, it is manufactured by methylating catechol (o-dihydroxybenzene). It is used medically as an expectorant, antiseptic, and local anesthetic; it is also a precursor to flavorants and aromas,聽.
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