Haplophytine is an insecticidal alkaloid that has been used since Aztec times. It was聽聽from the Mexican plant聽Haplophyton cimicidum聽by H. R. Snyder and co-workers in 1951. Its structure was聽聽by a research team led by P. Yates in 1967; but its total synthesis (in 29 steps!) wasn鈥檛 achieved until T. Fukuyama, H. Tokuyama, and colleagues聽聽it this year.
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