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Isopropyl alcohol (IPA; aka 2-propanol, but never 鈥渋sopropanol鈥�) is a common solvent, reagent, and disinfectant. It is flammable, with a characteristic odor that is similar to ethanol鈥檚, but more pungent.
IPA dates to 1866 in the chemical literature, when it was mentioned by Eduard Linnemann at the University of Lemberg (Poland)1 in an article about the . As described by Carleton Ellis in a 1921 article in Petroleum Magazine, IPA was by Standard Oil in 1920 from paraffin oil鈥揹erived propylene via its reaction with sulfuric acid, followed by hydrolysis. Much of the alcohol was then oxidized to acetone.
According to the Merck Index, IPA has a wide range of uses: in antifreeze compositions; as an industrial solvent for gums, resins, and creosote; in quick-drying inks and oils; in cosmetic products such as body rubs, hand lotions, and after-shave formulations; and in the manufacture of acetone, glycerol, and isopropyl acetate. It also has several medical uses, including in rubbing alcohol, hand sanitizers, and 鈥渨et wipes鈥�.
In 2022, the . It is forecast that the volume will grow to 鈮�2.9 million tonnes by 2030.
1. Now the University of Lviv (Ukraine).
Isopropyl alcohol听hazard information
Hazard class* | GHS code and hazard statement | |
---|---|---|
Flammable liquids, category 2 | H225鈥擧ighly flammable liquid and vapor | ![]() |
Serious eye damage/eye irritation, category 2A | H319鈥擟auses serious eye irritation | ![]() |
Specific target organ toxicity, single exposure, respiratory tract irritation, category 3 | H335鈥擬ay cause respiratory irritation | ![]() |
Specific target organ toxicity, single exposure, narcotic effects, category 3 | H336鈥擬ay cause drowsiness or dizziness | ![]() |
Specific target organ toxicity, repeated exposure (kidney, liver), category 2 | H373鈥擟auses damage to organs through prolonged or repeated exposure | ![]() |
*Globally Harmonized System (GHS) of Classification and Labeling of Chemicals.听.
Molecules from the journals
Indium zinc sulfide (In2Zn3S6)1 is a crystalline inorganic compound that was prepared in single-crystal sheets by USSR scientists V. F. Zhitar*, N. A. Goryunova, and S. I. Radautsan* in 1965. The authors described In2Zn3S6 as having photoelectric properties.
This January, Xue-Fang Yu, Kaisheng Zhang, Xiaolong Yang, and collaborators at Qingdao University, Yantai University, and the Chinese Academy of Sciences (Hefei, all in China) reported that In2Zn3S6, with sulfur vacancies, is an ideal photothermal catalyst for promoting the (e.g., propylene oxide2) to form cyclic carbonates. The authors propose that this reaction system could contribute to CO2 capture and the synthesis of useful materials.
顿颈丑测诲谤辞-尾-颈辞苍辞苍别3 is a cyclic unsaturated ketone first reported in 1934 by Leopold Ru啪i膷ka4* and W. Fischer at ETH Zurich in the of a series on polyterpenes and polyterpenoids. The article concentrated primarily on the synthesis of 1-尾-cyclogeranylgeraniol; but the authors also prepared dihydro-尾-ionone via the partial catalytic hydrogenation of 尾-ionone5.
顿颈丑测诲谤辞-尾-颈辞苍辞苍别 is one of several ionones (also known as 鈥渞ose ketones鈥�) that are components of flavor and fragrance products. In January, Su Bu, Longuo Zhao, and co-workers at Nanjing Forest University (China) described a biochemical synthesis of the molecule from glycerol6. They used an to produce dihydro-尾-ionone with a titer of 27 mg/L, considerably higher than the 8 mg/L obtained with E. coli alone.
1. CAS Reg. No. 12056-06-3.
2. CAS Reg. No. 75-56-9.
3. CAS Reg. No. 17283-81-7.
4. Ru啪i膷ka was a co- winner of the 1939 Nobel Prize in Chemistry for his work on polyethylene and terpenes.
5. CAS Reg. No. 79-77-6.
6. CAS Reg. No. 56-81-5.
Molecules from the Journals
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Isopropyl alcohol fast facts
CAS Reg. No. | 67-63-0 |
SciFinder nomenclature | 2-Propanol |
Empirical formula | C3H8O3 |
Molar mass | 60.10 g/mol |
Appearance | Colorless liquid |
Boiling point | 82.5 掳C |
Water solubility | Miscible |

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