What molecule am I?
Narciclasine, also known as lycoricidinol, is an isocarbostyril alkaloid found in the Amaryllidaceae (amaryllis) family of flowering plants. One notable genus of the family is Narcissus, from which narciclasine gets its name. Daffodils and jonquils are members of the Narcissus genus.
In 1967, Giovanni Ceriotti, Luigi Spandrio, and Annivale Gazzaniga at Circolo Hospital (Busto Arsizio, Italy) isolated narciclasine from Narcissus varieties. At that time, it was known to inhibit cell division. By the early 2010s, narciclasine was an established antitumor agent.
In 2016, Robert F眉rst at Goethe University (Frankfurt am Main, Germany) findings on narciclasine. At present, no clinical trials on narciclasine have been conducted on humans.
Narciclasine is sparingly soluble in water. But in 2003, George R. Petit and colleagues at Arizona State University (Tempe) at two of the adjacent hydroxyl groups of narciclasine. The product, which they called narcistatin (CAS Reg. no. ), is much more water-soluble (4 g/L), making it a valuable prodrug for narciclasine.
Narciclasine hazard information
| GHS classification*: germ cell mutagenicity, category 1B | |
| H340鈥擬ay cause genetic defects聽 |  |
*Globally Harmonized System of Classification and Labeling of Chemicals.聽.
Narciclasine fast facts
| CAS Reg. No. | 29477-83-6 |
| Molar mass | 307.26 g/mol |
| Empirical formula | C14H13NO7 |
| Appearance | White to off-white powder |
| Melting point | 246 潞C |
| Water solubility | Slight |
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