8-Oxoguanine, also known as its tautomer 8-hydroxyguanine, is a common DNA lesion that results from exposure to reactive oxygen species. In 2007, J. J. Collins and co-workers at Boston University showed that antibiotics with diverse targets kill bacterial cells by聽. More recently, Collins鈥檚 group and G. C. Walker and colleagues at MIT reported that guanine oxidation to 8-oxoguanine is bacterial聽.
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