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Palytoxin is a high–molecular mass fatty polyalcohol produced by zoanthid corals of the genus Palythoa. It is one of the most toxic nonprotein compounds known and contains one of the longest carbon chain of all naturally occurring molecules.

In 1971, Richard E. Moore and Paul. J Scheuer at the University of Hawaii (Honolulu) , a substance known to native Hawaiians as “limu-make-o-Hana�. The Hawaiian name translates as “seaweed of death from Hana�, but the authors quickly determined that P. toxica is a type of coral, not a seaweed.

Eleven years later, Moore and coauthors at Hawaii and Carnegie-Mellon University (Pittsburgh) published the . But earlier the same year, Yoshito Kishi, Yoshimasa Hirata, and colleagues at Harvard University, Shizuoka University (Japan), and Meijo University (Nagoya, Japan) published a at 11 of the 64 stereocenters.

In 1983, Yuzuru Shimizu at the University of Rhode Island (Kingston) wrote that Kishi and Hirata’s syntheses of palytoxin fragments constituted a superior method to Moore’s high-resolution NMR and thus . More than a decade later in 1994, Kishi and Edward M. Suh published .

The toxicity of palytoxin (see “Palytoxin hazard information�) has long been known, but a recent report illustrates how the poison can show up in unexpected places. A January article in Chemical and Engineering News described how P. toxica can lurk in home tropical aquariums  when they clean the rocks and corals in their tanks. Fortunately, warnings of this danger rapidly spread through forums and websites for aquarium hobbyists.