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Pentamidine, particularly as its diisethionate (di-2-hydroxyethanesulfonate) salt, is used to treat several infectious bacterial diseases. It has been used to treat African trypanosomiasis since 1937 and leishmaniasis since 1940. A US patent issued to British drug company May & Baker in 1946 describes its synthesis. It is usually administered by injection or inhalation.
Gram-negative bacteria, which have two sets of membranes, are difficult to control with standard antibiotics. Eric D. Brown and co-workers at McMaster University (Hamilton, ON) discovered that pentamidine can聽聽of multidrug-resistant Gram-negative bacteria such as聽Acinetobacter baumannii聽to allow antibiotics to penetrate the more permeable inner membrane.
This finding, if verified by clinical studies, should help decrease hospital-acquired infections caused by聽A. baumannii聽and other drug-resistant species. Because regulatory agencies consider pentamidine safe in humans, its registration for this use could be fast-tracked.
MOTW Update
Chlorpyrifos聽was the Molecule of the Week for聽November 8, 2010. Toward the end of the Obama administration, the US Environmental Protection Agency issued biological evaluations of three insecticides, including chlorpyrifos, on endangered species. Now, these products鈥� manufacturers are pressuring the agency to聽聽on the basis that they are flawed.
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