What molecule am I?
Tetraethyl orthosilicate (TEOS) is an ester of orthosilicic acid, which exists in small amounts in nature wherever silica is in contact with water. The ester is also known by several other names, including ethyl silicate (which is somewhat ambiguous), silicon tetraethoxide, and tetraethoxysilane.
In a landmark paper published in 1928, A. W. Dearing and E. Emmet Reid* at Johns Hopkins University (Baltimore) reported improved . TEOS was obtained in 70% yield by slowly adding silicon tetrachloride (SiCl4) to cold anhydrous ethanol, followed by removing byproduct hydrogen chloride with a stream of dry air. The reaction system must be rigorously free of water because even though TEOS is only slightly soluble in water, it hydrolyzes to form silica and ethanol. The reaction is the basis of modern TEOS production.
TEOS has multiple specialty uses, including stone hardening (which arrests the decay of structures and art objects), mortar and cement manufacture, and cross-linking silicone polymers. Its 2020 global market is for an estimated production of 鈮�120,000 t.
Tetraethyl orthosilicate hazard information
| Hazard class* | Hazard statement | |
|---|---|---|
| Flammable liquids, category 3 | H226鈥擣lammable liquid and vapor |  |
| Serious eye damage/eye irritation, category 2A | H319鈥擟auses serious eye irritation |  |
| Acute toxicity, inhalation, category 3 | H331鈥擳oxic if inhaled |  |
| Specific target organ toxicity, single exposure, respiratory tract irritation, category 3 | H335鈥擬ay cause respiratory irritation | |
聽*Globally Harmonized System of Classification and Labeling of Chemicals.
MOTW update
Scopolamine and its biochemical precursor hyoscyamine were the Molecules for the Week of聽October 21, 2013. Both are highly toxic and hallucinogenic. They are found in plants of the Solanaceae family such as deadly nightshade, mandrake, jimsonweed, and鈥攕urprisingly鈥攖omato. Despite their hazardous nature, both alkaloids are used in medicine. Recently, Christina D. Smolke* and Prashanth Srinivasan at Stanford University (CA) (brewer鈥檚 yeast) to produce hyoscyamine and scopolamine. The biosynthetic pathway is considered to be the longest and most complex to date for engineered yeast.
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Tetraethyl orthosilicate fast facts
| CAS Reg. No. | 78-10-4 |
nomenclature | Silicic acid (H4SiO4), tetraethyl ester |
| Empirical formula | C8H20O4Si |
| Molar mass | 208.33 g/mol |
| Appearance | Colorless liquid |
| Boiling point | 169 潞C |
| Water solubility聽 | 1.5 g/L (dec.) |
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