What molecule am I?
Titin1, also called connectin, is the largest known protein. It is found in the striated muscle tissue of humans and other vertebrates; homologous proteins exist in invertebrate animal families. Human titin is >1 碌m long and consists of 244 folded protein domains. Adults鈥� bodies contain 鈮�500 g of titin.
In 1954, Reiji Natori at the Jikei University School of Medicine (Tokyo) proposed an elastic structure in muscle to explain how muscles stretch and contract. The first of titin was reported in 1979 by Kuan Wang*, Janela McClure, and Ann Tu at the University of Texas at Austin. They used electrophoresis to purify 鈥渁 combination of two uncommonly large proteins, designated as titin, from chicken breast myofibrils鈥�. They concluded that titin is 鈥渁 structurally conserved myofibrillar component of vertebrate and invertebrate striated muscles鈥�.
Since the publication of Wang et al.鈥檚 pioneering work, a large body of research on titin has appeared. In 2019, Michael Gotthardt at the Max Delbr眉ck Center for Molecular Medicine, the Charit茅 University of Medicine, and the German Center for Cardiovascular Research (all in Berlin) and 11 collaborators in Germany, the United States, and Japan reported : how it is biosynthesized and integrated into the sacromere (the smallest functional unit of striated muscle tissue), and how it eventually detaches and degrades. The authors stated that there is still much to learn about titin synthesis and assembly.
A provides examples of additional research on titin.
1. From 鈥渢itan protein鈥�. Not to be confused with tutin, the Molecule of the Week for May 2, 2022.
Molecules from the journals
Antimony oxide iodide (Sb5O7I)1 is a first synthesized in 1972 by Volker Kr盲mer*, M. Schuhmacher, and R. Nitsche at the University of Freiburg (Germany). The researchers prepared Sb5O7I and other Sb(III)鈥揙鈥揑 compounds by combining Sb2O3 and SbI3 in various ratios via a vapor transport procedure.
Crystalline Sb5O7I exhibits nonlinear-optical behavior. In September, Mei Yang, Wenlong Liu*, and Sheng-Ping Guo* at Yangzhou University (China) reported that Sb5O7I crystals with a 2-D hexagonal noncentrosymmetric structure show a direct optical energy gap of 3.22 eV, the .
[Bis(trifluoroacetoxy)iodo]benzene2 [PIFA, from its alternative name phenyliodine bis(trifluoroacetate)] is an aromatic iodine(III)鈥搕rifluoroacetate compound that has become a valuable reagent in organic synthesis. It was first reported in 1973 by two research groups that used hypervalent iodine materials to study their reactions with silver salts and to prepare perfluoro- and perfluorochlorobenzenes.
PIFA is frequently used to carry out Hofmann rearrangements, in which it reacts with amides to eliminate carbon monoxide and form the corresponding amines. This September, in a sort of reversal to this reaction, Bill Morandi and co-workers at the Swiss Federal Institute of Technology (Z眉rich) used PIFA to to form quinoxalines.
1. CAS Reg. No. 37369-99-6.
2. CAS Reg. No. 2712-78-9.
Molecules from the Journals
MOTW briefly describes noteworthy molecules that appeared in recent ACS journal articles. See this week's edition.
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罢颈迟颈苍听fast facts
| CAS Reg. No. | 219575-37-8 |
| SciFinder nomenclature | Titins |
| Empirical formula | C169,719H270,466 N45,688O52,238S911 |
| Molar mass | 鈮�3.815 x 106 g/mol |
| Appearance | See |
| Melting point | Not reported |
| Water solubility | Portions soluble |
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