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ACS Omega

The yeastÌýCandida albicansÌýcan cause itchy, painful urinary tract and vaginal yeast infections. For women in low-resource settings who lack access to healthcare facilities, these infections create substantial social and economic burdens. Now, researchers reporting inÌýACS OmegaÌýhave developed color-changing threads that turn bright pink in the presence ofÌýC. albicans. When embedded in tampons or sanitary napkins, they could allow women to quickly and discreetly self-diagnose vulvovaginal yeast infections, the researchers say.

According to the Mayo Clinic, about 75% of women will experience a yeast infection, or vulvovaginal candidiasis, at least once in their lifetime. Although women in high-resource areas can easily be diagnosed with a vaginal swab at their doctor’s office and then treated with an antifungal medication, many women throughout the world lack access to basic healthcare facilities. Moreover, in some resource-limited areas, societal taboos cause women to feel shame or embarrassment about the symptoms, which prevents them from seeking a doctor’s care. Therefore, Naresh Kumar Mani and colleagues wanted to develop an inexpensive method that could be integrated into menstrual hygiene products, allowing women to quickly, easily and discreetly self-diagnose yeast infections.

The researchers began with ordinary multifilament cotton threads purchased at a local craft store. To increase the wicking properties of the threads, the team treated them with a heptane solution that removed waxes and binders added during manufacturing. Then, the threads were coated with a molecule called L-proline β-naphthylamide (PRO) â€� the substrate for an enzyme secreted byÌýC. albicansÌýâ€� and embedded in the inner layers of sanitary napkins and pads. When the researchers added simulated vaginal fluid spiked withÌýC. albicansÌýand an indicator solution, the spots of the napkins or pads containing yeast changed to a bright pink color. The detection time was only 10 minutes, compared with 24â€�72 hours for conventional tests. In addition, the new test costs only 22 to 28 cents per napkin or tampon, and it could easily be adapted to simultaneously detect other pathogens, such as bacteria that also can cause urinary tract infections, the researchers say.

The authors acknowledge funding from theÌýManipal Centre for Infectious Diseases, theÌýVision Group on Science and Technology of the Government of Karnataka, theÌýIndian Council of Medical ResearchÌýand theÌýScience and Engineering Research Board, Department of Science and Technology, Government of India.

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