Marathons are tough. Athletes push their bodies for miles and deal with cramping, dehydration and every runner鈥檚 worst fear: that extreme form of fatigue called 鈥渉itting the wall.鈥� Why is distance running so difficult? With the New York City Marathon kicking off this Sunday,听Reactions听runs through the science of distance running: why muscles burn, how sweat cools the body and the chemistry of runner鈥檚 high.